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Each 10C increase roughly doubles reaction rates, which is why refrigeration (versus room temperature) dramatically extends shelf life

The post lists fasting insulin, HbA1c, liver enzymes, renal function and baseline GLP-1 levels as the values that give clinical context for whether 5 mg is an appropriate starting point

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Many patients report feeling most stable and satisfied once they reach their personal target dose

Of the 31,327 eligible patients ( eTable 5 , describing the baseline characteristics of the unmatched cohort), 631 had been exposed to GLP-1RAs before ICU admission